Deepjyoti Ghosh

Predictability failure in glucose-insulin system for ICU patients

The paper shows that pulsatile insulin and step-wise glucose infusion in ICU patients can induce sustained chaos in the glucose-insulin system, limiting predictability of physiological responses.

Autoreactive antibody production by intrarenal B cells in mouse kidney allograft rejection

This study shows that autoreactive B cells in rejecting kidney allografts produce pathogenic IgG independently of donor-specific antibodies, highlighting a novel mechanism in antibody-mediated rejection.

Accounting for recurrent mutation in the frequency spectrum of rare alleles

The paper introduces the single mutation frequency spectrum (SMFS) to account for recurrent mutations in the site frequency spectrum of rare alleles, showing its application to human exome data.

Resolution of in situ inflammation in human lupus nephritis into principal immune cell trajectories

The paper quantifies immune cell populations in lupus nephritis and renal allograft rejection using microscopy and computational tools, identifying distinct inflammatory trajectories.