Author
University of CincinnatiORCID 0000-0003-0578-9250Unclaimed ORCID profile · follow to get notified of new preprints
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3 papers
Recent·Most cited
Bibek Karki, Jarek Meller, John T. Cunningham
This study analyzes PRPS enzyme evolution across domains of life, identifying new classes and regulatory mechanisms through phylogenetic and biochemical approaches.
Bibek R. Karki, Austin C. MacMillan, Sara Vicente-Muñoz…·John T. Cunningham
This study traces the evolutionary origins of mammalian PRPS genes and shows how their duplication and specialization enable functional multimeric complexes with regulatory features.
Austin C. MacMillan, Bibek Karki, Juechen Yang…·John T. Cunningham
This study identifies PRPS2 as a key regulator of redox homeostasis in Myc-driven lymphomas, showing that its inactivation causes reductive stress and cell death.