Author

Austin C. MacMillan

University of CincinnatiORCID 0000-0003-4240-1403Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Bibek R. KarkiiD· 2 shared John T. CunninghamiD· 2 shared Jarek MelleriD· 1 shared Jay A. PateliD· 1 shared Juechen YangiD· 1 shared Karmela R. GertziD· 1 shared Kenneth D. GreisiD· 1 shared Lindsey E. Romick‐RosendaleiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Bibek R. KarkiORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedJul 8, 2025

Evolutionary origins and innovations sculpting the mammalian PRPS enzyme complex

Bibek R. Karki, Austin C. MacMillan, Sara Vicente-Muñoz…·John T. Cunningham

This study traces the evolutionary origins of mammalian PRPS genes and shows how their duplication and specialization enable functional multimeric complexes with regulatory features.

11 citations

humanproteomics

𝕏 PostBluesky

Cancer BiologyRedox BiologyPeer-reviewedApr 25, 2025

PRPS activity tunes redox homeostasis in Myc-driven lymphoma

Austin C. MacMillan, Bibek Karki, Juechen Yang…·John T. Cunningham

This study identifies PRPS2 as a key regulator of redox homeostasis in Myc-driven lymphomas, showing that its inactivation causes reductive stress and cell death.

8 citations

mouseproteomics

𝕏 PostBluesky