Author

Denys A. Khaperskyy

Dalhousie UniversityORCID 0000-0003-0583-7179Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:differential expression· 1 Organism:human· 1 Assay:multiome· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Anastassia V. KomarovaiD· 1 shared Andrew MehleiD· 1 shared Caleb Galbraith· 1 shared Craig McCormickiD· 1 shared Deniz ÜresiniD· 1 shared Emily Andrews· 1 shared Jack Case· 1 shared Kaitlin A. Davis· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperMicrobiology

Anastassia V. KomarovaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologyCell ReportsPeer-reviewedOct 30, 2026

Influenza virus antagonizes self sensing by RIG-I to enhance viral replication

Mitchell P. Ledwith, Thomas Nipper, Kaitlin A. Davis…·Andrew Mehle

This study shows influenza virus uses its nucleoprotein to block RIG-I activation by host RNAs, thereby suppressing the antiviral response and enhancing viral replication.

2 citations

experimental assaywet-lab / biochemical assay

𝕏 PostBluesky

MicrobiologyPLoS PathogensPeer-reviewedFeb 9, 2026

Impaired host shutoff is a fitness cost associated with baloxavir marboxil resistance mutations in influenza A virus PA/PA-X nuclease domain.

Jack Case, Denys A. Khaperskyy

This paper shows that baloxavir resistance mutations in the PA protein impair host shutoff activity of PA-X, potentially limiting the spread of resistant influenza viruses.

2 citationstop 3%

experimental assayhost-pathogen & immune response

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Molecular BiologyRNAPeer-reviewedDec 17, 2025

Escape from SARS-CoV-2 Nsp1-mediated host shutoff by TIAR transcript reveals general features of Nsp1 resistance

Caleb Galbraith, Madeleine Stolz, Scott Tersteeg…·Denys A. Khaperskyy

The paper identifies sequence features in the TIAR 5' UTR that confer resistance to SARS-CoV-2 Nsp1 host shutoff, revealing shared characteristics with viral leader sequences.

3 citations

humanmultiome

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