Author

Mitchell P. Ledwith

University of Wisconsin–Madison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Andrew MehleiD· 2 shared Kaitlin A. Davis· 2 shared Anastassia V. KomarovaiD· 1 shared Anthony K. L. LeungiD· 1 shared Che-Yuan Chang· 1 shared Craig McCormickiD· 1 shared Deniz ÜresiniD· 1 shared Denys A. KhaperskyyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

Andrew MehleORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Influenza virus antagonizes self sensing by RIG-I to enhance viral replication

Mitchell P. Ledwith, Thomas Nipper, Kaitlin A. Davis, Deniz Üresin, Zhenyu Zhang, Mariel Kleer, Denys A. Khaperskyy, Craig McCormick, Anastassia V. Komarova, Andrew Mehle

This study shows influenza virus uses its nucleoprotein to block RIG-I activation by host RNAs, thereby suppressing the antiviral response and enhancing viral replication.

Cell Reports · Oct 30, 2026Peer-reviewedMicrobiology

Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection

Zhenyu Zhang, Isabel R. Uribe, Kaitlin A. Davis, Robert Lyle McPherson, Gloria P. Larson, Mohsen Badiee, Vy Tran, Mitchell P. Ledwith, Elizabeth M Feltman, Shuǐqìng Yú, Yíngyún Caì, Che-Yuan Chang, Xingyi Yang, Zhuo Ma, Paul Chang, , Andrew Mehle

The paper shows influenza A virus infection increases global ADP-ribosylation, which inhibits viral replication, and identifies PARP1 as the main enzyme involved, with NS1 counteracting this effect.

Nature Communications · Dec 17, 2025Peer-reviewedMicrobiology