Andrew Mehle

This study shows influenza virus uses its nucleoprotein to block RIG-I activation by host RNAs, thereby suppressing the antiviral response and enhancing viral replication.

The paper shows influenza A virus infection increases global ADP-ribosylation, which inhibits viral replication, and identifies PARP1 as the main enzyme involved, with NS1 counteracting this effect.

This study identifies RtmR, a membrane-bound RNA-binding protein in Vibrio fischeri, which inhibits biofilm formation by regulating the histidine kinase RscS.

This study shows IFIT3 binds RNA and enhances influenza A virus translation, revealing its pro-viral role during infection.

The paper identifies a single ANP32 locus in ticks that generates multiple variants supporting Thogoto virus polymerase activity, showing evolutionary plasticity across species.

This study identifies multiple UPR pathways that cooperate to link cytosolic dsDNA release to STING activation and IFN-β induction in response to ER stress.

The paper identifies cryptic proteins from deletion-containing viral genomes that inhibit influenza virus replication and expand its proteome.