Udeshika Kariyawasam

IL-27 Reduces Cell-Surface LDLR in Human Macrophages and Restricts VSV-G-Pseudotyped HIV infection

This study shows IL-27 reduces cell-surface LDLR in macrophages and limits VSV-G-pseudotyped HIV infection through receptor downregulation and post-entry mechanisms.

Beyond Metabolism: Pyruvate Carboxylase Acts as a Sequence-Selective Small RNA Sensor Orchestrating Antiviral Responses

The paper shows miRTC14 activates IFN expression through interaction with pyruvate carboxylase and LGP2, leading to TBK1 phosphorylation and IFN subtype production.

Human resistin is critical to activation of the NLRP3 inflammasome in macrophages

This study identifies hResistin's role in priming and activating the NLRP3 inflammasome in macrophages, linking it to inflammatory diseases through HMGB1, BTK, and downstream cytokine production.