Author

John Skinner

Brookhaven National LaboratoryORCID 0000-0002-0752-5438Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:clustering· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexei S. SoaresiD· 1 shared Andrea L. CoxiD· 1 shared Babak AndiiD· 1 shared Dieter K. SchneideriD· 1 shared Herbert Jacob BernsteiniD· 1 shared James FoadiiD· 1 shared Jean JakonciciD· 1 shared Lawrence C. AndrewsiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBioinformatics

Alexei S. SoaresORCID

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2 papers

Recent·Most cited

Human resistin is critical to activation of the NLRP3 inflammasome in macrophages

Udeshika Kariyawasam, JOHN T. SKINNER, Winson Lam, Rituparna Chakrabarti, Andrea L. Cox, Paul M. Hassoun, Qing Lin, Roger A. Johns

This study identifies hResistin's role in priming and activating the NLRP3 inflammasome in macrophages, linking it to inflammatory diseases through HMGB1, BTK, and downstream cytokine production.

PLoS ONE · Apr 10, 2026Peer-reviewedImmunology

Serial Crystallography with Multi-stage Merging of 1000s of Images

Alexei S. Soares, Yusuke Yamada, Jean Jakoncic, Sean M. McSweeney, Robert M. Sweet, John Skinner, James Foadi, Martin R. Fuchs, Dieter K. Schneider, Wuxian Shi, Babak Andi, Lawrence C. Andrews, Herbert Jacob Bernstein

The paper introduces a multi-stage clustering strategy for serial crystallography data to improve dataset merging accuracy by first clustering based on unit cell parameters and then on reflection intensities.

bioRxiv · Jun 19, 2022 · PreprintBioinformatics