Author

Helen M. Piwnica-Worms

The University of Texas MD Anderson Cancer CenterORCID 0000-0003-4210-6738Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Jiansu ShaoiD· 2 shared Sabrina L. Jeter-JonesiD· 2 shared Shirong CaiiD· 2 shared Aida Mestre‐FarreraiD· 1 shared Ajay Kumar SawiD· 1 shared Alastair Mark ThompsoniD· 1 shared Amanda L. RinkenbaughiD· 1 shared Anand K. Singh· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCell Biology

Jiansu ShaoORCID

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3 papers

Recent·Most cited

Cell BiologyProceedings of the National Academy of SciencesPeer-reviewedJun 23, 2026

Fasting primes small intestinal regeneration after damage via a microbiome metabolite chromatin axis

Praveen Barrodia, Ajay Kumar Saw, Sabrina L. Jeter-Jones…·Helen M. Piwnica-Worms

The paper identifies a fasting-induced microbiome-metabolite-chromatin axis that primes intestinal stem cells for regeneration after radiation injury.

1 citation

mousebulk RNA-seq

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Cancer BiologyNature CommunicationsPeer-reviewedMar 25, 2026

Extracellular matrix rigidity controls breast cancer metastasis via TYK2-mediated mechanotransduction

Zhimin Hu, Hannah E. Majeski, Aida Mestre‐Farrera…·Jane Yang

This study shows that TYK2 suppresses breast cancer metastasis under low ECM stiffness by promoting EMT, and its localization changes with ECM rigidity.

1 citation

humanorganoid / primary culture

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Cancer BiologyCancer ResearchPeer-reviewedAug 13, 2025

An annotated biobank of triple negative breast cancer patient-derived xenografts featuring treatment-naive and longitudinal samples throughout neoadjuvant chemotherapy

Amanda L. Rinkenbaugh, Yuan Qi, Shirong Cai…·Helen M. Piwnica-Worms

The paper establishes a biobank of TNBC patient-derived xenografts with treatment-naive and longitudinal samples to study chemoresistance and metastasis.

7 citations

humanbulk RNA-seq

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