MicrobiologybioRxivPreprint
Selective Disruption of Plasmodium falciparum mitochondrial DNA via G-Quadruplex-Binding Ligand RHPS4 Provides a Novel Antimalarial Strategy
Mariam Salim, Lucie Paloque, Thibaud Reyser…·Dennis Gómez
This study shows RHPS4, a G-quadruplex ligand, disrupts Plasmodium falciparum mitochondrial DNA and metabolism, offering a new antimalarial strategy by targeting mtDNA G4 structures.