Gregory M. Cresswell

Immune dysregulation in the prostates of C57BL/6Aire-/- mice mirrors that seen in human benign prostatic hyperplasia

This paper develops a mouse model of chronic prostatic inflammation that mirrors human BPH by showing similar immune and fibroblast features identified through scRNA-seq.

Immune cell single-cell RNA sequencing analyses link an age-associated T cell subset to symptomatic benign prostatic hyperplasia

The paper links an age-associated CD8+ T cell subset to symptomatic benign prostatic hyperplasia through immune aging mechanisms.

Infiltrating lipid-rich macrophage subpopulations identified as a regulator of increasing prostate size in human benign prostatic hyperplasia

The paper identifies lipid-rich macrophage subpopulations in BPH that correlate with prostate size and urinary symptoms.