Author

Matthew J. Fiedler

Houston MethodistORCID 0000-0003-0628-000XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:electrophysiology· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Alejandra Vásquez‐LimetaiD· 2 shared Ernesto Reyes-SancheziD· 2 shared Francisco J AltamiranoiD· 2 shared Leah CarteriD· 2 shared Christopher J. WardiD· 1 shared Monserrat Reyes-Lozano· 1 shared William M. PereziD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

Alejandra Vásquez‐LimetaORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BiophysicsAdvanced SciencePeer-reviewedOct 26, 2026

Human-engineered heart tissues recapitulate tissue-scale mechanisms underlying ventricular tachycardia

Matthew J. Fiedler, Alejandra Vásquez‐Limeta, Ernesto Reyes-Sanchez…·Francisco J Altamirano

This paper demonstrates that human iPSC-derived engineered heart tissues can replicate tissue-scale mechanisms of ventricular tachycardia, including APD dispersion and reentry, previously only observed in intact hearts.

DOI 10.1002/advs.78429

humanelectrophysiology

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PhysiologybioRxivPreprintMar 24, 2026

Polycystin-1 C-Terminus Regulates Protein Synthesis-Related Pathways in Cardiomyocytes

Matthew J. Fiedler, Alejandra Vásquez‐Limeta, Ernesto Reyes-Sanchez…·Francisco J Altamirano

This study shows that PC1-CT in cardiomyocytes activates PI3K-Akt-mTOR-S6K1-S6 signaling to enhance protein synthesis pathways without inducing canonical hypertrophy.

DOI 10.64898/2026.03.21.713243

humanmouse

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