Ernesto Reyes-Sanchez

Human-engineered heart tissues recapitulate tissue-scale mechanisms underlying ventricular tachycardia

This paper demonstrates that human iPSC-derived engineered heart tissues can replicate tissue-scale mechanisms of ventricular tachycardia, including APD dispersion and reentry, previously only observed in intact hearts.

Polycystin-1 C-Terminus Regulates Protein Synthesis-Related Pathways in Cardiomyocytes

This study shows that PC1-CT in cardiomyocytes activates PI3K-Akt-mTOR-S6K1-S6 signaling to enhance protein synthesis pathways without inducing canonical hypertrophy.

Polycystin-1 loss of function increases susceptibility to atrial fibrillation through impaired DNA damage response