Author

Zachary L. Sebo

Northwestern UniversityORCID 0000-0003-2495-9083Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Alec R. KossiD· 1 shared CHRISTOPHER D. CHURCH· 1 shared Colleen R. ReczekiD· 1 shared Jenna L. E. BlumiD· 1 shared Karis B. D’AlessandroiD· 1 shared Matthew S. RodehefferiD· 1 shared Navdeep S. ChandeliD· 1 shared Ram Prosad ChakrabartyiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPhysiology

Alec R. KossORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintOct 2, 2025

Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycemic control

Zachary L. Sebo, Ram Prosad Chakrabarty, Rogan A. Grant…·Navdeep S. Chandel

This study shows metformin lowers blood glucose by inhibiting intestinal mitochondrial complex I, increasing lactate and GDF15, and promoting glucose uptake.

2 citations

mousehuman

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Developmental BiologybioRxivPreprintAug 7, 2020

Adipose tissue developmental growth constraints uncouple fat distribution from glucose metabolism in two mouse models of obesity

Zachary L. Sebo, CHRISTOPHER D. CHURCH, Ryan Berry, Matthew S. Rodeheffer

The paper investigates how fat distribution affects glucose metabolism in two mouse obesity models, finding that subcutaneous fat expansion does not worsen metabolic health.

DOI 10.1101/2020.08.07.239665

mousebulk RNA-seq

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