Logan R. Myler

This study shows that TRF2 tetramerization forms t-loops, protecting telomeres from ATM signaling and cNHEJ by sequestering telomere ends.

The paper shows DNA-PK and TRF2 inhibit MRN resection at blunt telomeres, preventing fusion through alternative end joining.

This study shows DNA-PK promotes MRN and phosphorylated CtIP for efficient DNA end processing, facilitating the transition from non-homologous end joining to homologous recombination.