Titia de Lange

Attenuation of ATM signaling by ROS delays replicative senescence at physiological oxygen

The paper shows that reduced ATM signaling via ROS at physiological oxygen delays replicative senescence by inhibiting DDR activation.

Tetrameric TRF2 forms t-loop to protect telomeres from ATM signaling and cNHEJ

This study shows that TRF2 tetramerization forms t-loops, protecting telomeres from ATM signaling and cNHEJ by sequestering telomere ends.

DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres

The paper shows DNA-PK and TRF2 inhibit MRN resection at blunt telomeres, preventing fusion through alternative end joining.

Loose ends in cancer genome structure

The paper identifies 'loose ends' in cancer genomes, structural variations missed by short-read WGS, and estimates they account for <3% of large-scale structural variation.

Structural variant evolution after telomere crisis

The paper investigates structural variants (SVs) generated during telomere crisis, showing that BFB cycles and chromothripsis can occur in clones that escape telomere crisis.

APOBEC3B-dependent kataegis and TREX1-driven chromothripsis in telomere crisis

This study identifies TREX1 and APOBEC3B as key drivers of chromothripsis and kataegis during telomere crisis in cancer.

Novel patterns of complex structural variation revealed across thousands of cancer genome graphs

The paper identifies three novel complex structural variation patterns in cancer genomes using genome graph analysis across 2,833 tumor WGS.