Mitochondrial Proteome of Affected Neurons in a Mouse Model of Leigh Syndrome
Alejandro Gella, Patricia Prada-Dacasa, Montserrat Carrascal, Andrea Urpi, Melania González-Torres, Joaquín Abián, Elisenda Sanz, Albert Quintana
The paper uses a novel viral tool to isolate mitochondria from affected neurons in a mouse model of Leigh Syndrome, revealing proteomic and acetylomic changes associated with mitochondrial dysfunction.
Frontiers in Cell and Developmental Biology · Jul 28, 2020Peer-reviewedNeuroscience