Andrea Urpi

MET inhibition exploits conserved regulatory dependencies in malignant rhabdoid tumors

This study identifies MET signaling as a targetable vulnerability in rhabdoid tumors through integrated single-cell multi-omic and spatial transcriptomics analyses.

Spatio-temporal T cell tracking for personalized TCR-T designs in childhood cancer

This study tracks T cell dynamics in a pediatric cancer patient post-ICI therapy to identify tumor-reactive TCRs for personalized TCR-T cell therapy.

Maltodextrin administration ameliorates brain pathology in a mouse model of mitochondrial disease

This study shows that maltodextrin improves lifespan and reduces microglial reaction in Ndufs4KO mice, a model of mitochondrial disease, but does not improve locomotion or respiratory function.

Vestibular CCK neurons drive motion-induced malaise

The paper identifies CCK-expressing vestibular neurons as key drivers of motion-induced malaise and shows their role in inducing conditioned taste aversion through parabrachial nucleus activation.

Mitochondrial Proteome of Affected Neurons in a Mouse Model of Leigh Syndrome

The paper uses a novel viral tool to isolate mitochondria from affected neurons in a mouse model of Leigh Syndrome, revealing proteomic and acetylomic changes associated with mitochondrial dysfunction.