Damiano Cianferoni

The paper evaluates AI and first-principle methods for protein redesign, showing hybrid approaches are most reliable, while inverse folding tools and force fields have specific strengths and limitations.

This paper introduces EvolveX, a computational pipeline for designing stable single-domain antibodies with high affinity, demonstrating improved binding affinity to human targets.

The paper introduces a workflow for IP-MS data to detect differentially present bait proteoforms, offering insights into protein function through peptidoform analysis.

The paper identifies Srrm3-dependent microexons as critical for photoreceptor function and vision, showing their role in outer segment maintenance and their loss leading to blindness.