Javier Delgado

The paper evaluates AI and first-principle methods for protein redesign, showing hybrid approaches are most reliable, while inverse folding tools and force fields have specific strengths and limitations.

This paper introduces EvolveX, a computational pipeline for designing stable single-domain antibodies with high affinity, demonstrating improved binding affinity to human targets.

VarQ assesses the functional impact of single amino acid substitutions on protein activity, folding, and interactions using curated variants.