Author

Sarah Frail

Stanford MedicineORCID 0000-0003-0718-3092Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 1 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Ellen YehiD· 2 shared Jon DoenieriD· 2 shared Adrien BurlacotiD· 1 shared Apratim MitraiD· 1 shared Daniel J. LeeiD· 1 shared Dimitri TolleteriD· 1 shared Giovanni FinazziiD· 1 shared Joyce J. ThompsoniD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

Ellen YehORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologyProceedings of the National Academy of SciencesPeer-reviewedJun 17, 2026

A genome-wide CRISPR screen reveals how diatoms thrive in dynamic light

Jon Doenier, Dimitri Tolleter, Sarah Frail…·Ellen Yeh

A genome-wide CRISPR screen in diatoms identifies genes critical for survival under different light conditions, including a novel gene involved in cyclic electron flow.

3 citationstop 5%

multiple speciesgenetic perturbation / CRISPR

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Evolutionary BiologyProceedings of the National Academy of SciencesPeer-reviewedAug 12, 2025

Genomes of nitrogen-fixing eukaryotes reveal a non-canonical model of organellogenesis

Sarah Frail, Melissa C. Steele-Ogus, Jon Doenier…·Ellen Yeh

The paper analyzes genomes of nitrogen-fixing eukaryotes to show that endosymbionts can function as integral cell compartments without significant genetic integration.

12 citationstop 1%

whole-genome sequencingexperimental assay

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GenomicsNature CommunicationsPeer-reviewedJul 23, 2022

Rapid redistribution and extensive binding of NANOG and GATA6 at shared regulatory elements underlie specification of divergent cell fates

Joyce J. Thompson, Daniel J. Lee, Apratim Mitra…·Pedro P. Rocha

The paper shows GATA6 and NANOG bind shared regulatory elements to drive divergent cell fates in mouse blastocysts by modulating chromatin accessibility and transcriptional activation.

49 citations

mouseChIP-seq

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