Victoria J. McParland

This study identifies a microbiome-AhR-IL-17A axis that drives CKD-associated cardiac fibrosis and shows that AhR inhibition prevents remodeling.

The paper compares mucus-associated microbiota sampling methods in mice and humans, finding that mucosal washes yield less host contamination and comparable microbiota diversity to biopsies and scrapings.

The paper develops methods to collect intestinal interstitial fluid from different segments and shows segment-specific differences in microbiota-derived metabolites, cytokines, and proteins compared to plasma and serum.