Author

Jawahar Sudhamsu

GenentechORCID 0000-0003-0737-2299Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Alexis L. RohouiD· 1 shared Angela Oh· 1 shared Anqi ZhuiD· 1 shared Benjamin HaleyiD· 1 shared Christine C. JaoiD· 1 shared Christopher M. KothiD· 1 shared Christopher P. ArthuriD· 1 shared Dimitry TegunoviD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiophysics

Alexis L. RohouORCID

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2 papers

Recent·Most cited

BiophysicsNature CommunicationsPeer-reviewedSep 30, 2025

Disulfide constrained Fabs overcome target size limitation for high-resolution single-particle cryo-EM

Jennifer E. Kung, Matthew Camp Johnson, Dimitry Tegunov…·Jawahar Sudhamsu

This paper introduces Rigid-Fabs, disulfide-constrained antibody fragments that enable high-resolution cryo-EM structures of small proteins by overcoming size limitations.

12 citations

cryo-EMexperimental assay

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Molecular BiologyCell ReportsPeer-reviewedJun 1, 2024

Accelerated drug resistant variant discovery with an enhanced, scalable mutagenic base editor platform

Kristel M. Dorighi, Anqi Zhu, Jean‐Philippe Fortin…·Benjamin Haley

The paper develops a scalable mutagenic base editor platform to identify drug-resistant variants in cancer genomes efficiently.

10 citations

humanwhole-exome sequencing

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