Matthew Camp Johnson

This paper introduces cryoSHIELDs, tunable peptides that improve cryo-EM sample preparation by modulating the air-water interface, enhancing particle distribution and complex integrity across multiple protein systems.

This paper introduces Rigid-Fabs, disulfide-constrained antibody fragments that enable high-resolution cryo-EM structures of small proteins by overcoming size limitations.

The paper designs binary 2D protein co-assemblies that form ordered, biologically active materials with potential therapeutic applications.

The paper reports cryo-EM structures of human IMPDH2 showing filament assembly tunes allosteric regulation and reduces feedback inhibition.