NeurosciencebioRxivPreprint
CLIP-Seq Analysis Enables the Design of Ribosomal RNA Bait Oligonucleotides That Protect Against C9orf72 ALS/FTD-Associated Poly-GR Pathophysiology
Juan Alberto Ortega, Ivan R. Sasselli, Marco Boccitto…·Evangelos Kiskinis
The paper identifies that poly-GR binds ribosomal RNA and shows that modified rRNA oligonucleotides can mitigate poly-GR toxicity in models of C9orf72 ALS/FTD.
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