Juan Alberto Ortega

The paper shows mechanical cues induce nuclear remodeling linked to radial glia-like competence across species, using a model based on nuclear geometry and cell density.

The paper identifies that poly-GR binds ribosomal RNA and shows that modified rRNA oligonucleotides can mitigate poly-GR toxicity in models of C9orf72 ALS/FTD.

The paper identifies eRF1 and NMD as modifiers of C9orf72 repeat expansion toxicity by analyzing nucleocytoplasmic proteomic changes in ALS/FTD.

The paper introduces an all-optical electrophysiology method called Optopatch to functionally characterize human iPSC-derived motor neurons in ALS models, finding altered electrophysiological properties in SOD1 A4V mutants.