Alexander R. Ziegler

This study uses N-terminomics to show that CatC inhibition by brensocatib reduces NSP abundance and alters protease-antiprotease network dynamics in HL-60 cells.

This paper introduces an on-bead PAC/SP3 derivatization method for C- and N-terminomics, demonstrating its application in identifying C-terminal peptides and analyzing termini in Jurkat cells.

This study investigates the role of cathepsin S and X in inflammatory bowel diseases using activity-based probes and mouse models, finding that cathepsin S contributes to some symptoms but pharmacologic inhibition may have unintended effects.

This study investigates the relationship between legumain and cathepsins, showing legumain is required for cathepsin processing and nuclear localization of cathepsin L, with implications for cell proliferation and other nuclear functions.