Laura E. Edgington‐Mitchell

The paper profiles deubiquitinase (DUB) activity and abundance in dendritic cells under unstimulated and CpG-stimulated conditions using activity-based probes and proteomics.

This study uses N-terminomics to show that CatC inhibition by brensocatib reduces NSP abundance and alters protease-antiprotease network dynamics in HL-60 cells.

This paper introduces an on-bead PAC/SP3 derivatization method for C- and N-terminomics, demonstrating its application in identifying C-terminal peptides and analyzing termini in Jurkat cells.

This study compares how two intralysosomal pathogens, C. burnetii and L. mexicana, affect lysosomal proteolytic activity and proteome changes in host cells.

This study investigates the role of cathepsin S and X in inflammatory bowel diseases using activity-based probes and mouse models, finding that cathepsin S contributes to some symptoms but pharmacologic inhibition may have unintended effects.

This study identifies PfK13 mutations as drivers of artemisinin resistance by enhancing antioxidant defenses, which can be counteracted by sulforaphane.

This study investigates the relationship between legumain and cathepsins, showing legumain is required for cathepsin processing and nuclear localization of cathepsin L, with implications for cell proliferation and other nuclear functions.