This study uses N-terminomics to show that CatC inhibition by brensocatib reduces NSP abundance and alters protease-antiprotease network dynamics in HL-60 cells.

bioRxiv · Sep 7, 2026 · PreprintBiochemistry

Intralysosomal pathogens differentially influence the proteolytic potential of their niche

Lauren E. Bird, Bangyan Xu, David R. Thomas, Erin N.S. McGowan, Patrice Newton, Nichollas E. Scott, Malcolm John McConville, Laura E. Edgington‐Mitchell, Hayley J. Newton

This study compares how two intralysosomal pathogens, C. burnetii and L. mexicana, affect lysosomal proteolytic activity and proteome changes in host cells.

Infection and Immunity · Dec 30, 2025Peer-reviewedMicrobiology

Probing the activity of cysteine cathepsins in inflammatory bowel diseases

Bethany M. Anderson, Alexander R. Ziegler, Rhiannon I. Campden, Hongyi Wu, Bangyan Xu, Rachel Mai McQuade, Simona Carbone, Daniel P. Poole, Alan E. Lomax, David E. Reed, Stephen J. Vanner, Robin M. Yates, Nigel W. Bunnett, Laura E. Edgington‐Mitchell

This study investigates the role of cathepsin S and X in inflammatory bowel diseases using activity-based probes and mouse models, finding that cathepsin S contributes to some symptoms but pharmacologic inhibition may have unintended effects.

Scientific Reports · Dec 23, 2025Peer-reviewedPathology

Legumain drives processing of cathepsins and nuclear localisation of cathepsin L

Alexander R. Ziegler, Bangyan Xu, Bethany M. Anderson, L. Y. Liu, Stephanie Luedtke, Joanna Sacharz, David A. Stroud, Nichollas E. Scott, Laura E. Edgington‐Mitchell

This study investigates the relationship between legumain and cathepsins, showing legumain is required for cathepsin processing and nuclear localization of cathepsin L, with implications for cell proliferation and other nuclear functions.

bioRxiv · Aug 17, 2025 · PreprintBiochemistry