Bethany M. Anderson

Probing the activity of cysteine cathepsins in inflammatory bowel diseases

This study investigates the role of cathepsin S and X in inflammatory bowel diseases using activity-based probes and mouse models, finding that cathepsin S contributes to some symptoms but pharmacologic inhibition may have unintended effects.

PfK13-associated artemisinin resistance slows drug activation and enhances antioxidant defence, which can be overcome with sulforaphane.

This study identifies PfK13 mutations as drivers of artemisinin resistance by enhancing antioxidant defenses, which can be counteracted by sulforaphane.

Legumain drives processing of cathepsins and nuclear localisation of cathepsin L

This study investigates the relationship between legumain and cathepsins, showing legumain is required for cathepsin processing and nuclear localization of cathepsin L, with implications for cell proliferation and other nuclear functions.