Rogerio Bastos Craveiro

The paper uses single-cell RNA sequencing to analyze PDL cells from maxilla and mandible pairs, finding uniform mesenchymal populations with donor-specific substates and limited jaw-related transcriptional differences.

This study identifies a novel mechanism in myelofibrosis where a single mutation drives both bone formation and resorption, revealing THBS1 as a therapeutic target.

The paper shows that Wnt-dependent reprogramming of bone marrow niches drives fibrosis by activating osteolineage cells and altering hematopoietic support.