Mélanie Königshoff

This study shows that loss of TFAM in alveolar type 2 cells leads to mitochondrial dysfunction and fibrosis by promoting senescence and a profibrotic secretory program.

This study analyzes lung epithelial cells across the lifespan in mice, identifying age-related declines in regeneration linked to inflammation and epigenetic changes.

This study shows that Siglec-F protects against elastase-induced lung inflammation and emphysema by regulating airspace macrophages in mice.

The paper uses single-cell RNA-seq to analyze aging effects on lung regeneration, identifying immune cell states linked to impaired progenitor function in aged mice.

This paper introduces DeepSAS, a deep graph framework to identify senescent cells and their associated genes, revealing cell-type-specific senescence features in aging and disease.

Single-nucleus multiomic and ex vivo lung slice profiling of human idiopathic pulmonary fibrosis identifies Alveolar Intermediate cells bridging alveolar and Aberrant Basaloid states and reveals AP-1 chromatin injury memory.

The paper develops SenSet, a gene signature for human lung senescence, validated in 3D culture models and identifies cell-type specific senescence mechanisms in aging and disease.

The paper uses single-cell RNA-seq to identify Krt8+ progenitor cells involved in lung regeneration and shows their role in epithelial differentiation and disease.