Author

Paul A. Welling

Johns Hopkins UniversityORCID 0000-0002-0719-8705Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

Benjamin D. HumphreysiD· 2 shared Eryn E. DixoniD· 2 shared Hao WuiD· 2 shared Nicolas LedruiD· 2 shared Owen M. WoodwardiD· 2 shared Parker C. WilsoniD· 2 shared Terry J. WatnickiD· 2 shared Alexis HofherriD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersGenomics

Benjamin D. HumphreysORCID

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4 papers

Recent·Most cited

Kidney kallikrein-1 contributes to cleavage of gamma-ENaC in vivo

Joshua N. Curry, Xiaotong Su, Qi Wu, Yujiro Maeoka, Chao‐Ling Yang, Eric J. Delpire, Robert A. Fenton, Paul A. Welling, David H. Ellison

This study shows that kidney kallikrein-1 contributes to gamma-ENaC cleavage but is not essential for overall ENaC function or electrolyte balance.

American Journal of Physiology-Renal Physiology · Feb 11, 2026Peer-reviewedPhysiology

Extra-ciliary role for polycystins in regulation of Ezrin and renal tubular morphology

Eryn E. Dixon, Ava M. Zapf, Victoria L. Halperin Kuhns, Denis Basquin, Rachel M. Park, Richard A. Coleman, Lidiya Franklin, Allison C. Lane-Harris, Alexis Hofherr, Michael Köttgen, Feng Qian, Paul A. Welling, Terry J. Watnick, Owen M. Woodward

This study identifies an extra-ciliary role for polycystins in regulating Ezrin and renal tubular morphology through phosphorylation and localization changes.

bioRxiv · Nov 5, 2025 · PreprintCell Biology

Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis

Yoshiharu Muto, Eryn E. Dixon, Yasuhiro Yoshimura, Hao Wu, Kohei Omachi, Nicolas Ledru, Parker C. Wilson, Andrew J. King, N. Eric Olson, Marvin G. Gunawan, Jay J. Kuo, Jennifer H. Cox, Jeffrey H. Miner, Stephen L. Seliger, Owen M. Woodward, , Benjamin D. Humphreys

This study uses single-cell multiomic analysis to define cellular complexity in ADPKD, identifying novel transcriptomic and epigenomic features in cystic kidney cells.

Nature Communications · Oct 30, 2022Peer-reviewedGenomics

The Single Cell Transcriptomic Landscape of Early Human Diabetic Nephropathy

Parker C. Wilson, Hao Wu, Yuhei Kirita, Kohei Uchimura, Nicolas Ledru, Helmut G. Rennke, Paul A. Welling, Sushrut S. Waikar, Benjamin D. Humphreys

This study uses snRNAseq to analyze early diabetic nephropathy in human kidneys, identifying gene expression changes in potassium secretion and angiogenic signaling across multiple cell types.

Proceedings of the National Academy of Sciences · Sep 10, 2019Peer-reviewedGenomics