Author

Hongying Shen

Yale UniversityORCID 0000-0002-2115-7037Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Xiaojian ShiiD· 2 shared Agnes Roczniak-FergusoniD· 1 shared Alfred Kibowen· 1 shared Amer BalabakiiD· 1 shared Andre Luiz Teles e Silva· 1 shared Annabel SeniD· 1 shared April PruittiD· 1 shared Charlotte Becker· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

Xiaojian ShiORCID

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3 papers

Recent·Most cited

JIP4 deficiency causes a novel lysosome storage disease arising from impaired cystine efflux

Layla M. Nassar, Xiaojian Shi, Agnes Roczniak-Ferguson, Hongying Shen, Shawn M. Ferguson

This study shows that JIP4 deficiency causes lysosomal cystine accumulation by reducing CTNS levels, mimicking cystinosis in human cells and mice.

bioRxiv · Jun 6, 2025 · PreprintCell Biology

An in vivo screen identifies NAT10 as a master regulator of brain metastasis

Jocelyn Fang-Yi Chen, Peng Xu, Wesley L. Cai, Huacui Chen, Emily Wingrove, Xiaojian Shi, Wenxue Li, Giulia Biancon, Meiling Zhang, Amer Balabaki, Ethan D. Krop, Elianna Asare, Yangyi Zhang, Mingzhu Yin, Toma Tebaldi, , Qin Yan

This study identifies NAT10 as a master regulator of brain metastasis through an in vivo shRNA screen and shows its role in promoting tumor growth and metastasis via downstream effectors.

Science Advances · Mar 26, 2025Peer-reviewedCancer Biology

Dynamic convergence of neurodevelopmental disorder risk genes across neurodevelopment

Meilín Fernández García, Kayla G. Townsley, April Pruitt, Elizabeth Davidson, Novin Balafkan, Jonathan Warrell, Tzu-Chieh Huang, Alfred Kibowen, Zhiyuan Chu, Yi Dai, Sarah E. Fitzpatrick, Ran Meng, Annabel Sen, Sophie Cohen, Olivia Livoti, , Kristen Brennand

This study identifies convergent biological pathways in mature neurons affected by neurodevelopmental disorder risk genes and shows drug candidates can ameliorate behavioral phenotypes.

bioRxiv · Aug 23, 2024 · PreprintGenetics