Nicolás Alcaraz

CREPAS is a Nextflow pipeline for analyzing nascent chromatin sequencing data, improving scalability, reproducibility, and compatibility across multiple chromatin assays.

The paper introduces nucCAGE and PRIME to identify active cis-regulatory elements with high sensitivity and applies them to create a cell-type-resolved CRE atlas.

This study shows that FACT is essential for chromatin replication and transcription by disrupting and reassembling nucleosomes, preventing genome aggregation.

This study shows that retrotransposon expression increases with age in axolotls but decreases during limb regeneration, suggesting a role in age-related regenerative decline.

The paper examines how promoter sequence and transcription start site architecture influence expression variability and genetic variant effects in human genes.

The paper analyzes genomic profiles of Mexican Testicular Germ Cell Tumor patients to identify biomarkers of platinum sensitivity, finding that CNV amplification of 2q11.1 may indicate chemosensitivity.

The paper characterizes transposon-derived regulatory elements in mouse embryonic stem cells, showing their role in gene regulation and pluripotency programs.

The paper identifies GBAF as an enhancer-associated chromatin remodeler that interacts with H3K27ac and is essential for enhancer transcription.