Author

R. Ciaran MacKenzie Frater

University of CopenhagenORCID 0009-0002-4701-6598Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Anja GrothiD· 2 shared Alexander van OudenaardeniD· 1 shared Anton Lunow Bournonville· 1 shared Hannah J. RichteriD· 1 shared Jeroen van den BergiD· 1 shared Ji‐Joon SongiD· 1 shared Joaquim Ollé-LópeziD· 1 shared Jongha Yoon· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMolecular Biology

Anja GrothORCID

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2 papers

Recent·Most cited

Unified function of FACT in mammalian chromatin replication and transcription, dissolving and restoring nucleosomes to counteract genome aggregation

R. Frater, Rikke Rejnholdt Jensen, Joaquim Ollé-López, Valentin Flury, Jeroen van den Berg, Anton Lunow Bournonville, Nicolás Alcaraz, Simai Wang, Hannah J. Richter, Marty G. Yang, Qian Du, Alexander van Oudenaarden, Vijay Ramani, Nils Krietenstein, Anja Groth

This study shows that FACT is essential for chromatin replication and transcription by disrupting and reassembling nucleosomes, preventing genome aggregation.

bioRxiv · Feb 26, 2026 · PreprintMolecular Biology

CODANIN-1 sequesters ASF1 by using a histone H3 mimic helix to regulate the histone supply

Tae‐Kyeong Jeong, R. Ciaran MacKenzie Frater, Jongha Yoon, Anja Groth, Ji‐Joon Song

This study determines the structure of the CODANIN-1_ASF1 complex, revealing how CODANIN-1 inhibits ASF1-mediated histone supply by sequestering ASF1 in the cytoplasm.

Nature Communications · Mar 4, 2025Peer-reviewedBiophysics