Jason K. K. Low

This study identifies PRDM9 as a factor promoting survival of drug-tolerant persister cells in glioblastoma through metabolic rewiring and cholesterol biosynthesis.

This study reports the high-resolution cryo-EM structure of native human nucleosomes from HEK293 cells and provides mass spectrometry analysis of histone modifications.

The paper identifies cyclic peptides that selectively inhibit BET BD paralogues by exploiting sequence differences and conformational dynamics, achieving high selectivity over existing inhibitors.

This study shows that SET-25 and SET-32 are needed for establishing but not maintaining transgenerational epigenetic silencing in C. elegans, indicating distinct genetic steps in the process.