Integrating bacterial genomics and host transcriptomics links Burkholderia pseudomallei variation to melioidosis mortality and neutrophil responses
Arin Wongprommoon, Phumrapee Boonklang, Katie L Burnham…·Claire Chewapreecha
Author
Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom;ORCID 0000-0003-0867-2867Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Arin Wongprommoon, Phumrapee Boonklang, Katie L Burnham…·Claire Chewapreecha
Matheswaran Kandasamy, Hana F. Andrew, Iwan G. A. Raza…·Alexander J. Clarke
This study shows that GSK3 is essential for Treg development and function, as its loss leads to metabolic changes, pro-inflammatory gene expression, and enhanced anti-tumoral immunity.
Megan R. Teh, Nancy Gudgeon, Joe N. Frost…·Hal Drakesmith
This study shows iron deficiency impairs CD8+ T cell proliferation and metabolism by disrupting mitochondrial function, but exogenous aspartate can rescue this defect.