Kevin A. Mills

A novel pipeline for the validation of manganese chelators for the treatment of manganese overload

This paper develops a pipeline to identify and evaluate novel manganese chelators using zebrafish and mouse models, finding that H3PyC3A and Me3PyC3A show improved manganese mobilization and reduced accumulation.

Multi-Omic Analysis Reveals Lipid Dysregulation Associated with Mitochondrial Dysfunction in Parkinson's Disease Brain

This study identifies lipid dysregulation linked to mitochondrial dysfunction in Parkinson's Disease brain regions through multi-omics analysis of lipids, proteomics, and mitochondrial activity.

The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosis

This study shows that the SNCA A53T mutation increases vulnerability to ferroptosis in neurons and microglia, suggesting 15-LO inhibition as a potential therapeutic target for Parkinson's disease.

Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region

This study shows that extracellular tau's synaptotoxic effects are mediated by its microtubule-binding region, and targeting this region can reverse synaptic plasticity disruption.

Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease

The paper compares proteome and transcriptome changes in DSAD brains to AD and healthy controls, finding elevated APOE in specific cell types.

The diversity of SNCA transcripts in neurons, and its impact on antisense oligonucleotide therapeutics

The paper identifies novel SNCA transcripts in human dopaminergic neurons and demonstrates their impact on antisense oligonucleotide therapy for Parkinson's disease.