David M. Dinh

This study identifies structural determinants of catalytic bias in SaAcs1, showing that residues G196 and T197 in the CoA-binding loop influence the preference for AMP formation.

The paper identifies a novel antiphage system, Panoptes, that uses a minimal CRISPR polymerase to produce cyclic nucleotides and detects phage anti-defense proteins through effector binding and nucleotide depletion.