Christoph Klein

The paper identifies suppressive atypical memory B cells in AML that are amplified by CAR T cell interactions and shows that targeting both B cells and AML blasts can overcome this suppression.

This paper develops a mouse model of severe congenital neutropenia caused by VPS45 mutations, showing similar neutropenia and functional defects as in humans.

The paper presents a CITE-seq atlas of human neonatal immune development, identifying a 32-week gestational transition to interferon-primed immunity.

This study shows that VPS18 mutations disrupt neutrophil maturation by impairing vesicle dynamics and autophagy, leading to neutropenia and recurrent infections.

The paper generates intestinal organoids from pediatric IBD patients and controls to study epithelial phenotypes linked to genetic drivers of the disease, identifying gene expression patterns and pathways associated with inflammation.

This study examines how different TTC7A missense mutations in pediatric IBD patients lead to distinct intestinal epithelial phenotypes.

This study identifies KRT17 as a mediator of platinum resistance and a biomarker for targeted therapy in ovarian cancer using organoid models and clinical data.