Daniel Kotlarz

SATB1 is a targetable modulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells

This study identifies SATB1 as a regulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells, showing its potential as a target for CAR T cell therapy.

Longitudinal modality prediction learns gene regulatory patterns: insights from a single-cell competition

The paper presents a longitudinal multimodal benchmarking dataset and competition to evaluate modality prediction methods for gene regulatory inference, showing top models outperform existing approaches.

A niche-dependent redox rheostat regulates epithelial stem cell fate in the distal colon

This study shows that redox balance, regulated by NOX1 and HIF1-IDH1 interactions, controls epithelial stem cell fate in the distal colon niche.

A collection of patient-derived intestinal organoid lines reveals epithelial phenotypes associated with genetic drivers of pediatric inflammatory bowel disease

The paper generates intestinal organoids from pediatric IBD patients and controls to study epithelial phenotypes linked to genetic drivers of the disease, identifying gene expression patterns and pathways associated with inflammation.

Distinct heterozygous TTC7A missense variants lead to different intestinal epithelial phenotypes in pediatric IBD

This study examines how different TTC7A missense mutations in pediatric IBD patients lead to distinct intestinal epithelial phenotypes.