Yusaku Iwasaki

The vagus nerve drives cognitive function through the default mode network

This study shows that vagus nerve stimulation activates the default mode network, enhancing cognitive behaviors, while vagal-independent mechanisms affect the salience network.

Gut-derived GLP-1 released by rare sugar D-allulose cooperates with insulin to activate left-sided vagal afferents and enhance insulin sensitivity

This paper shows that D-allulose-induced GLP-1 enhances insulin action via left-sided vagal afferents, improving glucose tolerance more effectively than GLP-1 receptor agonists in mice.

Exacerbation of sucrose-induced visceral obesity and glucose intolerance by ovariectomy and its GLP-1-dependent amelioration by the rare sugar D-allulose

This study shows that D-allulose reduces visceral obesity and glucose intolerance in ovariectomized mice, with effects dependent on GLP-1.

Lateralized vagal oxytocin signaling separately controls feeding and socioemotional functions via hypothalamic oxytocin signaling

This study shows that left and right vagal oxytocin signaling differentially control feeding and socioemotional behaviors via hypothalamic oxytocin neurons in mice.

A vagal sensory--hypothalamic oxytocin--brown adipose tissue pathway mediates cholecystokinin-induced thermogenesis

This study identifies a vagal sensory-hypothalamic oxytocin-brown adipose tissue pathway that mediates CCK-induced thermogenesis.

A skeletal muscle-sympathetic nerve-intestine network underlies muscle inflammation and atrophy induced by immobilization

This study identifies a muscle-sympathetic nerve-intestine network that drives inflammation and atrophy in immobilized muscles, showing that intestinal inflammation contributes to muscle damage.