Author

Ángel Fernández‐Trasancos

Spanish National Centre for Cardiovascular ResearchORCID 0000-0002-0382-5409Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

David Sánchez-OrtiziD· 2 shared Diana Velázquez-CarrerasiD· 2 shared Fátima Sánchez‐CaboiD· 2 shared Jorge Alegre‐CebolladaiD· 2 shared Laura Sen-MartíniD· 2 shared Lucía Sánchez-GarcíaiD· 2 shared María Rosaria PricoloiD· 2 shared Miguel Ángel López-UnzuiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

David Sánchez-OrtizORCID

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2 papers

Recent·Most cited

Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy

Laura Sen-Martín, Ángel Fernández‐Trasancos, Miguel Ángel López-Unzu, Agata Bak, Magdalena Zafra-Castellano, Rajiven Srikantharajah, Divya Pathak, Annika J. Klotz, Michel N. Kuehn, Alessia Ferrarini, Verónica Labrador-Cantarero, David Sánchez-Ortiz, María Rosaria Pricolo, Natalia Vicente, Diana Velázquez-Carreras, , Jorge Alegre‐Cebollada

This study shows that myosin inhibition with mavacamten is effective in treating HCM caused by both truncating and missense variants in MYBPC3, despite different pathomechanisms.

Nature Cardiovascular Research · Jul 7, 2026Peer-reviewedPhysiology

Titin cleavage is a driver of cardiomyocyte disengagement and reactive myocardial fibrosis

Miguel Ángel López-Unzu, María Rosaria Pricolo, Roberto Silva‐Rojas, Alejandro Clemente-Manteca, David Sánchez-Ortiz, Natalia Vicente, Diana Velázquez-Carreras, Cristina Morales, Manuel Gavilán-Herrera, Laura Sen-Martín, Ángel Fernández‐Trasancos, Verónica Labrador-Cantarero, Lucía Sánchez-García, Carlos Relaño‐Rupérez, Fátima Sánchez‐Cabo, , Jorge Alegre‐Cebollada

This study shows that titin cleavage drives cardiomyocyte disengagement and fibrosis in heart disease, contributing to myocardial remodeling.

bioRxiv · Apr 22, 2025 · PreprintPhysiology