Author

Wai Kit Chan

Simons Initiative for the Developing BrainORCID 0000-0002-8097-0802Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

John O. MasoniD· 3 shared David Jonathan PriceiD· 2 shared Neil Cowan HendersoniD· 2 shared Zrinko KozićiD· 2 shared Abhay S. PanditiD· 1 shared Beth E. P. HendersoniD· 1 shared Catalina Vallejo‐GiraldoiD· 1 shared Dániel Dobolyi· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersDevelopmental Biology

John O. MasonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Loss of PAX6 alters the excitatory/inhibitory neuronal ratio in human cerebral organoids

Wai Kit Chan, Shibla Abdulla, Lusi Zhao, Danilo Negro, Victoria M Munro, Sophie R. Thomson, Helen Marshall, Zrinko Kozić, Megan Brown, Michela Barbato, Mariana Beltrán, Neil Cowan Henderson, David Jonathan Price, John O. Mason

This study shows that PAX6 deficiency in human cerebral organoids leads to an increased inhibitory neuron population and altered excitatory/inhibitory ratio due to dysregulated PTN-PTPRZ1 signaling.

Development · Oct 26, 2026Peer-reviewedDevelopmental Biology

Cerebral Organoids with Integrated Endothelial Networks Emulate the Neurovascular Unit and Mitigate Core Necrosis

Josep Fumadó Navarro, Siobhan Crilly, Wai Kit Chan, S. Browne, John O. Mason, Catalina Vallejo‐Giraldo, Abhay S. Pandit, Mihai Lomora

Embedding day-8 cerebral organoids in Geltrex loaded with human brain microvascular endothelial cells, plus VEGF-supplemented mixed media, yields integrated endothelial networks and almost three-fold less apoptosis.

Advanced Science · Aug 30, 2025Peer-reviewedBioengineering✦ In-depth digest

PAX6 LIMITS THE COMPETENCE OF DEVELOPING CEREBRAL CORTICAL CELLS

Martine N. Manuel, Kai Boon Tan, Zrinko Kozić, Michael Molinek, Tiago Sena Marcos, Fazilah Maizatul Abdul Razak, Dániel Dobolyi, Ross Dobie, Beth E. P. Henderson, Neil Cowan Henderson, Wai Kit Chan, Michael I. Daw, John O. Mason, David Jonathan Price

This study shows that Pax6 limits the competence of developing cortical progenitors to respond to morphogens, preventing inappropriate lineage generation.

bioRxiv · Feb 3, 2022 · PreprintNeuroscience