Peter Brodersen

The paper identifies that tryptophan-binding pockets in Arabidopsis AGO1 are essential for RDR6-dependent siRNA amplification through interactions with SGS3.

The paper shows PUMILIO and m6A-YTHDF proteins share mRNA targets and have opposing roles in plant organogenesis.

The paper shows ALBA proteins interact with YTHDF proteins to facilitate m6A reading in Arabidopsis, expanding the understanding of m6A regulatory mechanisms in plants.

This study identifies two roles of terminal nucleotidyl transferases (TNTases) in secondary siRNA amplification in Arabidopsis, showing URT1 inhibits initiation while HESO1 and others promote siRNA formation by modifying dsRNA.

The paper identifies a YTHDF-PABP interaction essential for m6A-mediated organogenesis in Arabidopsis by showing that ECT2's IDR elements bind PAB proteins to promote leaf formation.

The paper investigates the molecular functions of YTHDF proteins across land plants, showing conserved ancestral functions and lineage-specific diversification in Arabidopsis.

The paper identifies interaction hubs in the N-terminal domain of plant ARGONAUTE1, showing distinct regions involved in binding regulatory factors like autophagy receptors and F-box proteins.

The paper identifies an N-terminal region in AGO proteins that is accessible in the RNA-free state and mediates specific degradation through interaction with ATI1.

The paper investigates how nuclear and cytoplasmic RNA exosomes and PELOTA1 prevent miRNA-induced secondary siRNA production in Arabidopsis by analyzing mutant phenotypes and molecular mechanisms.

The paper identifies overlapping mRNA targets of ECT2 and ECT3 using HyperTRIBE and shows they regulate target mRNA abundance, not alternative polyadenylation.

The paper identifies ECT2 binding sites in Arabidopsis m6A-containing mRNAs using iCLIP and HyperTRIBE, revealing sequence preferences and competition with other RNA-binding proteins.

The paper investigates how mRNA structure affects miRNA cleavage in vivo using a new method in Arabidopsis thaliana, finding that target site unfolding and a downstream motif determine cleavage efficiency.

The paper reassesses the existence of PROMPTs and eRNAs in Arabidopsis thaliana using RNA sequencing in nuclear decay mutants, identifying exosome-sensitive transcripts and antisense RNAs.

This paper investigates the molecular properties of Arabidopsis autophagy cargo receptors ATI1 and ATI2, showing their intrinsically disordered regions and post-translational modifications upon ATG8 interaction.