Author

Tina Tylek

Drexel UniversityORCID 0000-0003-1102-8431Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Kara L. SpilleriD· 2 shared Ajay S. ThatteiD· 1 shared Alex G. HamiltoniD· 1 shared Alvin J. Mukalel· 1 shared Benjamin I. Binder‐MarkeyiD· 1 shared C. Pritchett FrazeeiD· 1 shared Carl H. JuneiD· 1 shared Christian G. Figueroa‐EspadaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBioengineering

Kara L. SpillerORCID

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2 papers

Recent·Most cited

BioengineeringBioengineering & Translational MedicinePeer-reviewedMar 30, 2026

Bioinspired Oxidized mRNA Lipid Nanoparticles for Ex Vivo Engineering of Chimeric Antigen Receptor Macrophages Targeting Solid Tumors

Alvin J. Mukalel, Tina Tylek, Hannah C. Geisler…·Michael J. Mitchell

This paper develops a bioinspired oxidized lipid nanoparticle platform for mRNA-based engineering of CAR-Ms to target solid tumors, showing improved delivery and tumor-killing efficacy.

2 citations

humanexperimental assay

𝕏 PostBluesky

Bioengineeringnpj Regenerative MedicinePeer-reviewedFeb 12, 2025

Effects of injury size on local and systemic immune cell dynamics in volumetric muscle loss

Ricardo C. Whitaker, Samuel Sung, Tina Tylek…·Kara L. Spiller

This study examines how injury size affects immune cell dynamics in muscle repair, finding early macrophage dysfunction and increased neutrophils in fibrotic outcomes.

9 citations

mousebulk RNA-seq

𝕏 PostBluesky