Author

Ajay S. Thatte

University of PennsylvaniaORCID 0000-0001-7372-8893Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:multiome· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Hannah C. GeisleriD· 4 shared Michael J. MitchelliD· 4 shared Hannah C. SaffordiD· 3 shared Alex G. HamiltoniD· 2 shared Christian G. Figueroa‐EspadaiD· 2 shared Drew WeissmaniD· 2 shared Hannah M. YamagataiD· 2 shared Lulu XueiD· 2 shared

Activity by Year

2021-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersBioengineering

Hannah C. GeislerORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

BioengineeringAdvanced MaterialsPeer-reviewedJul 21, 2026

Resolving heterogeneity of targeted lipid nanoparticles through solution-based biophysical analyses

Hannah C. Geisler, Hannah C. Safford, Ajay S. Thatte…·Michael J. Mitchell

This study resolves heterogeneity in targeted lipid nanoparticles (tLNPs) using biophysical methods, showing that subpopulation structure, not bulk properties, determines targeted RNA delivery.

DOI 10.1002/adma.73984

mousedeep learning

𝕏 PostBluesky

BioengineeringBioengineering & Translational MedicinePeer-reviewedMar 30, 2026

Bioinspired Oxidized mRNA Lipid Nanoparticles for Ex Vivo Engineering of Chimeric Antigen Receptor Macrophages Targeting Solid Tumors

Alvin J. Mukalel, Tina Tylek, Hannah C. Geisler…·Michael J. Mitchell

This paper develops a bioinspired oxidized lipid nanoparticle platform for mRNA-based engineering of CAR-Ms to target solid tumors, showing improved delivery and tumor-killing efficacy.

2 citations

humanexperimental assay

𝕏 PostBluesky

BioengineeringAdvanced MaterialsPeer-reviewedJan 28, 2026

High-throughput in vivo screening using barcoded mRNA identifies lipid nanoparticles with extrahepatic tropism for cancer immunotherapy

Alex G. Hamilton, Ajay S. Thatte, Junchao Xu…·Michael J. Mitchell

15 citationstop 1%

mousemultiome

𝕏 PostBluesky

BioengineeringbioRxivPreprintNov 12, 2025

Anti-CD38-Targeted Piperazine-Derived Lipid Nanoparticles Overcome Hepatic Clearance for mRNA Delivery to Multiple Myeloma Cells In Vivo

Christian G. Figueroa‐Espada, Hannah C. Geisler, Ryann A. Joseph…·Michael J. Mitchell

This study develops anti-CD38 lipid nanoparticles for targeted mRNA delivery to multiple myeloma cells, improving tumor targeting and reducing hepatic accumulation.

DOI 10.1101/2025.11.12.687398

mousemultiome

𝕏 PostBluesky

Molecular BiologyBiophysical JournalPeer-reviewedJan 30, 2021

Clathrin senses membrane curvature

Wade F. Zeno, Jacob B. Hochfelder, Ajay S. Thatte…·Jeanne C. Stachowiak

This study shows clathrin is a strong membrane curvature sensor, with its sensitivity amplified by adaptor proteins, highlighting the role of protein networks in curvature sensing.

41 citationstop 4%

experimental assay

𝕏 PostBluesky