Author

Aaron J. Golas

Broad InstituteORCID 0000-0003-1153-756XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:bacteria (other)· 1 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

Deborah Tan HungiD· 2 shared Michael G. FitzGeraldiD· 2 shared Noam Shoresh FiD· 2 shared Allison Lemmer· 1 shared Andras BoeszoermenyiiD· 1 shared Austin N. BondiD· 1 shared Bradley E. PoulseniD· 1 shared Christopher M. SassettiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMicrobiology

Deborah Tan HungORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintFeb 15, 2025

Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis

Austin N. Bond, Marek Orzechowski, Shuting Zhang…·Deborah Tan Hung

This paper introduces PCL analysis to predict small molecule mechanisms of action in Mycobacterium tuberculosis using PROSPECT data, achieving high sensitivity and precision in MOA prediction.

2 citations

deep learningdrug response / drug discovery

𝕏 PostBluesky

MicrobiologyCell chemical biologyPeer-reviewedDec 27, 2024

Multiplexed screen identifies a Pseudomonas aeruginosa-specific small molecule targeting the outer membrane protein OprH and its interaction with LPS

Bradley E. Poulsen, Thulasi Warrier, Sulyman Barkho…·Deborah Tan Hung

The paper identifies a Pseudomonas aeruginosa-specific small molecule, BRD1401, that targets OprH and disrupts its interaction with LPS, increasing membrane fluidity.

11 citations

bacteria (other)experimental assay

𝕏 PostBluesky