Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis
Austin N. Bond, Marek Orzechowski, Shuting Zhang, Ishay Ben-Zion, Allison Lemmer, Nathaniel Garry, Katie Lee, Michael J. Chen, Kayla Delano, Emily Gath, Aaron J. Golas, Raymond M. Nietupski, Michael G. FitzGerald, Sabine Ehrt, Eric J. Rubin, , Deborah Tan Hung
This paper introduces PCL analysis to predict small molecule mechanisms of action in Mycobacterium tuberculosis using PROSPECT data, achieving high sensitivity and precision in MOA prediction.
bioRxiv · Feb 15, 2025 · PreprintMicrobiology